Aminoacyl-tRNA synthetases (AARSs) attach amino acids to their cognate transfer RNAs (tRNAs) in the first reaction of protein synthesis. This essential reaction occurs in all domains of life, and AARSs enforce the specificity for amino acids and tRNAs in translation by use of additional editing mechanisms. They represent a validated large family of target for anti-infective, anti-cancer agents, many of which are approved medicines. Investigations of AARSs have provided the theoretical and experimental framework for their modification to insert new amino acids into proteins, a rapidly growing subfield of biotechnology and synthetic biology. Since 2000, the AARS field has additionally been transformed by discoveries of novel regulatory roles in eukaryotic physiology, and the characterization of their intricate relationship to human diseases, such as neurological disorder and cancer.
With the positive memories of Barcelona still fresh in our minds, we look forward to bringing together ~150 scientists from all over the world to discuss the frontiers of research with respect to these housekeeping proteins, the origin of genetic coding, the translational apparatus, their diverse roles in protein synthesis, as well as non-translational functions and physiological regulation in human disease. With the able assistance of everyone, we are pleased to announce that the 11th such meeting, AARS2017, will be held at Clearwater Beach, Florida from October 29th to November 2nd, 2017.
11th International Symposium on Aminoacyl-tRNA Synthetase - AARS2017